产品说明
一般描述
The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.
生化/生理作用
The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.
Kinase assays.
单位定义
One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.
外形
Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.
法律信息
Brij is a registered trademark of Croda International PLC
基本信息
| MDL编号 | MFCD03458482 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged) |
| 形式 | buffered aqueous solution |
| 分子量 | ~48 kDa by SDS-PAGE |
| UniProt登记号 | O00141 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... SGK1(6446) |
Sigma-Aldrich
m.cnreagent.com
