Anti-SLIPR/MAGI-3 antibody produced in rabbit

产品说明

一般描述

MAGI-3 possesses a guanylate-kinase-like region, six PDZ and two WW domains. This gene is located on human chromosome 1p13.
The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.²

MAGI-3 (also termed SLIPR) was identified in a two hybrid screening as a protein interacting with the tumor suppressor PTEN,⁶ and Receptor Tyrosine Phosphatase β (RPTPβ).⁷

特异性

Staining by immunoblotting and immunofluorescence is specifically inhibited by the immunizing peptide.

免疫原

synthetic peptide corresponding to amino acids 835-850 of SLIPR (rat homolog of MAGI-3) conjugated to KLH via a N-terminal added lysine residue.

生化/生理作用

Membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) serves as a scaffold protein for frizzled-4 and Ltap . It helps to control the c-Jun N-terminal kinase (JNK) signaling cascade.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide as a preservative.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质