Anti-Sodium Channel PN1 antibody produced in rabbit

产品说明

一般描述

Sodium channel protein type 9 subunit alpha (SCN9A) is encoded in human chromosome location 2q24.3. SCN9A is also called the Nav1.7. Sodium channel protein type 9 subunit alpha, (SCN9A) encodes nine isoforms in human and they are majorly expressed in cells of peripheral nervous system.

免疫原

synthetic peptide corresponding to amino acids 446-460 of rat PN1 (with additional N-terminal cysteine). This epitope is highly conserved in rabbit and human.

生化/生理作用

They function to generate and conduct electrical impulses in neuronal membranes. SCNA9 mutations is associated with epilepsy in infant dravet syndrome. Nonsense mutations in SCNA9 gene leads to loss sensation towards pain. Missense mutations in SCNA9 results in primary erythermalgia and paroxysmal extreme pain disorder.

外形

Lyophilized from a solution containing phosphate buffered saline, pH 7.4, 1% bovine serum albumin, and 0.05% sodium azide.

基本信息

产品性质