产品说明
一般描述
Monoclonal anti-Cytokeratin Peptide 7 (mouse IgG1 isotype) is derived from the hybridoma produced the fusion of mouse myeloma cells and splenocytes of an immunized mouse. Cytokeratins are the intermediate filaments of endocrine cells. These proteins belongs to the intermediate filament (10 nm) superfamily of cytoskeletal proteins. Cytokeratin 7 (CK 7/ KRT7) is a low molecular weight cytokeratin. It is present in epithelial tissues of lung, breast and ovary.
Keratin, type II cytoskeletal 7 is a protein encoded by the KRT7 gene in humans. It is also known as cytokeratin-7 (CK-7), keratin-7 (K7), sarcolectin (SCL) and K2C7. Keratin 7 is a type II keratin and is a member of the keratin gene family. It is found on chromosome 12. It is specifically expressed in the simple epithelia lining of the internal organs and in the gland ducts as well as blood vessels.
特异性
The antibody reacts specifically with most simple epithelia but shows no reaction with epithelial cells in the intestine or in the stomach.
免疫原
cytoskeletal preparation of the RT4 human bladder carcinoma cell line.
应用
Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse has been used in:
生化/生理作用
Cytokeratins may play an important role in transhepatic transport and canalicular secretion. Cytokeratin 7 (CK 7/ KRT7) only stains bile ducts in normal liver, hence it is considered as “bile duct keratin”. CK 7 is widely used in surgical pathology. It acts as a specific marker for mammary and extramammary Paget′s disease.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00162253 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | ascites fluid |
| antibody product type | primary antibodies |
| 克隆 | LDS-68, monoclonal |
| 包含 | 15 mM sodium azide |
| species reactivity | human |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable immunohistochemistry (frozen sections): suitable indirect immunofluorescence: 1:200 using formalin-fixed, paraffin-embedded sections of human and animal tissue microarray: suitable western blot: suitable |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | P08729 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... KRT7(3855) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
