产品说明
应用
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) is a preservative used as a standard for quantifying preservatives in pharmaceutical formulations by using capillary electrophoretic method. It has also been used to anesthetize leeches for preparing c-DNA library from regenerating retzius cells.
生化/生理作用
Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.
基本信息
| 线性分子式 | Cl3CC(CH3)2OH · 0.5H2O |
| 分子量 | 186.46 |
| Beilstein | 878167 |
| EC 号 | 249-042-3 |
| MDL编号 | MFCD02179352 |
| PubChem化学物质编号 | 57647873 |
产品性质
| 质量水平 | 200 |
| 测定 | 98-100.5% (calc with ref. to anhyd. subst.) |
| 质量 | meets analytical specification of Ph. Eur., BP, NF |
| 杂质 | ≤0.002% heavy metals (as Pb) 4.5-5.5% water (Karl Fischer) |
| 灼烧残渣 | ≤0.1% (as SO4) |
| mp | 76-80 ℃ |
| 痕量阴离子 | chloride (Cl-): ≤100 mg/kg |
| application(s) | pharmaceutical (small molecule) |
| SMILES string | O.CC(C)(O)C(Cl)(Cl)Cl.CC(C)(O)C(Cl)(Cl)Cl |
| InChI | 1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2 |
| InChI key | WRWLCXJYIMRJIN-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 预防措施声明 | P301 + P312 + P330 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | 212.0 °F - closed cup |
| 闪点(C) | 100 ℃ - closed cup |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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