产品说明
一般描述
Fibronectin 1 (FN1) is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. It is mapped to human chromosome 2q35. Fibronectin is mostly synthesized by fibroblasts and endothelial cells.
应用
Epithelial cells, mesenchymal cells, neuronal cells, fibroblasts, neural crest cells, endothelial cells
Fibronectin human foreskin fibroblasts has been used in extracellular matrix binding assay and probiglycan and cleavage assays. It has also been used in ectoderm (neuronal) differentiation and in the preparation of a semi-solid growth medium.
包装
0.5 mg in serum bottle
生化/生理作用
Fibronectin 1 (FN1) participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Fibronectin production by normal human foreskin fibroblasts has been shown to improve two-fold after glucocorticoid treatment.
注意
本品复原后，不建议涡漩、过度搅拌、反复冻融。
外形
Lyophilized in CAPS buffered saline
制备说明
dialyzed against chloroform
重悬
Store reconstituted solution in working aliquots at -20℃ or lower.
分析说明
蛋白质均一性由免疫电泳评估。
基本信息
| EC 号 | 289-149-2 |
| MDL编号 | MFCD00131062 |
| NACRES | NA.75 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human foreskin fibroblasts |
| 产品线 | BioReagent |
| 形式 | lyophilized powder |
| 分子量 | ~550 kDa |
| 包装 | pkg of 0.5 mg |
| technique(s) | cell culture | mammalian: suitable |
| 表面覆盖度 | 1‑5 μg/cm2 |
| 溶解性 | H2O: 1 mg/mL at 37 ℃ (Store reconstituted solution in working aliquots at -20℃ or lower.) |
| web metadata keyword.default | attachment factor, mesenchymal cell attachment, neuronal cell attachment, fibroblast attachment, neural crest cell attachment, endothelial cell attachment |
| UniProt登记号 | P02751 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... FN1(2335) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
