产品说明
一般描述
UBE2K, also known as UbcH1 or E2-25K, is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Once an E1 is carrying an activated ubiquitin in a ubiquitin-E1 thiolester complex, this activated ubiquitin is transferred to the active site cysteine of the E2 to form a ubiquitin-E2 thiolester complex. With the aid of an E3, the activated ubiquitin is then targeted to a specific substrate lysine. UBE2K is a biochemically important E2 due to its ability to form free K48-linked polyubiquitin chains in solution in the absence of an E3. This ability is attributed to UbcH1 possessing a C-terminal UBA domain, in addition to its E2 catalytic domain. UBE2K takes part in many cellular processes such as selective protein degradation, DNA repair, cell cycle control, and sporulation. In addition, UBE2K is involved in Alzheimer′s disease, Huntington′s disease and antigen processing through its interaction with amyloid-?, Huntington, and MHC-heavy chain proteins.
外形
75 μL of a 40 μM solution (3 nmoles) in TBS.
制备说明
Centrifuge the vial prior to opening.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | 22.406 kDa |
| 包装 | pkg of 3 nmol |
| NCBI登记号 | P61086 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... UBE2K(3093) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 |
| 预防措施声明 | P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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