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Anti-TGN46 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200355
规格纯度
clone TGN46-8, purified from hybridoma cell culture
参考价格
5045.46 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-TGN46 antibody, Mouse monoclonal
Anti-Trans-Golgi network protein, 46-kD
产品介绍:

产品说明

一般描述

Trans-Golgi network integral membrane protein 2 (TGOLN2), also known as trans-Golgi network 46 (TGN46), is encoded by the gene mapped to human chromosome 2p11.2. It is a heterodimeric type I integral membrane protein. TGOLN2 has a highly conserved N terminus, which consists of a signal peptide. The C terminus possesses a lumenal domain, a membrane spanning region and cytoplasmic tail.

免疫原

synthetic peptide corresponding to the C-terminal region of human TGN46, conjugated to KLH. The corresponding sequence is identical in monkey and differs by 3 amino acids in rat and mouse TGN46.

生化/生理作用

Trans-Golgi network integral membrane protein 2 (TGOLN2) cycles between the trans-Golgi network (TGN) and the cell surface via an early endosomal compartment. This movement is mediated by a tyrosine-based tetra peptide signal (SDYQRL) in the cytoplasmic domain. It plays an important role in the formation of exocytic vesicles at the TGN by functioning as a receptor for complexes of a cytoplasmic protein known as p62 and one GTP-binding protein. The cytoplasmic domain of TGOLN2 binds to the complex and is essential for budding process. It mediates the coupling of the segregation of secretory proteins to the budding of exocytic vesicles. The cytosolic domain of TGOLN2 interacts with AP2 clathrin adaptor complexes and also with the coiled coil region of a protein called neurabin.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD09265378
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆TGN46-8, monoclonal
形式buffered aqueous solution
分子量 80-100 kDa
species reactivityhuman
浓度~1.0 mg/mL
technique(s)indirect immunofluorescence: 5-10 μg/mL using HeLa cells
western blot: 2-4 μg/mL using whole extracts of HEK-293T cells over-expressing human TGN46
同位素/亚型IgG1
UniProt登记号O43493
运输dry ice
储存温度−20℃
Gene Informationhuman ... TGOLN2(10618)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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