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Monoclonal Anti-Neurofilament 160 antibody produced in mouse

品牌
Sigma-Aldrich
货号
N2787
规格纯度
~2 mg/mL, clone RMO44, purified immunoglobulin, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-Neurofilament 160 antibody produced in mouse
Anti-Neurofilament Medium Chain
产品介绍:

产品说明

一般描述

Neurofilament 160 (NEFM) is one among the most abundant filaments in post-mitotic neurons.
Monoclonal Anti- Neurofilament 160 (mouse IgG1 isotype) is derived from the hybridoma RMO44 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified mid-sized rat neurofilament (NF-M) subunit. Neurofilaments are one of the five major groups of intermediate filaments (Ifs) and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kDa, 160 kDa and 200 kDa.

免疫原

purified mid-sized rat neurofilament (NF-M) subunit.

应用

Monoclonal Anti-Neurofilament 160 antibody produced in mouse has been used in:

  • enzyme-linked immunosorbent assay (ELISA)
  • western blot analysis
  • immunohistochemistry
  • antibody labelling

生化/生理作用

Neurofilament 160 (NEFM) associates with the dopamine receptor.
Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals. These molecules undergo post-translational modifications, which results in their heterogeneity including different levels of phosphorylation. The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing their interaction with cytoplasmic organelles.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01322393
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆RMO44, monoclonal
形式buffered aqueous solution
species reactivityrat, human, mouse, zebrafish
浓度~2 mg/mL
technique(s)immunohistochemistry: suitable
microarray: suitable
western blot: 1-2 μg/mL using extract of SHSy5y human neuroblastoma cells
同位素/亚型IgG1
UniProt登记号P07197
运输dry ice
储存温度−20℃
Gene Informationhuman ... NEFM(4741)
mouse ... Nefm(18040)
rat ... Nefm(24588)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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