产品说明
一般描述
NTF3 (neurotrophin 3) is a neurotrophic factor belonging to the NGF (nerve growth factor) family. This protein is made up of 257 amino acids, with a prepro region of 138 amino acids and the mature sequence of 119 residues.
应用
Neurotrophin-3 human has been used in the magnetic sorting of oligodendrocyte progenitor cells.
生化/生理作用
Neurotrophin-3 (13.6 kDa or 27.2 kDa dimer) is a member of the neurotrophin family. It has identical amino acid sequence in human, mouse, and pig with full cross-reactivities. NT-3 is important in development and maintenance of neuronal populations and promotes differentiation of neural crest derived sensory and sympathetic neurons. It is critical for proprioceptive 1a afferent neurons, which relay information from peripheral muscle spindles to motoneurons, sending projections to spinocerebellar neurons. NT-3 is also critical in the superior cervical and nodose ganglia.
外形
Lyophilized from a 0.2 m filtered solution in phosphate buffered saline (PBS) containing 50 μg of bovine serum albumin (BSA) per 1 μg of cytokine.
分析说明
The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.
基本信息
| MDL编号 | MFCD00212404 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in baculovirus infected Sf21 cells |
| 测定 | >97% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 1-40 ng/mL EC50 |
| 包装 | pkg of 5 μg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P20783 |
| 储存温度 | −20℃ |
| Gene Information | human ... NTF3(4908) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
