产品说明
一般描述
Filter Code: PCF
Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.
MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.
Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput
Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1
PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3
MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.
应用
Research Category
Assays
Protein
外形
Color Code: 透明
其他说明
Automation Compatible: No
法律信息
MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
eCl@ss | 32039006 |
NACRES | NB.22 |
产品性质
物料 | flat bottom wells polycarbonate membrane polystyrene |
质量水平 | 400 |
无菌性 | non-sterile |
产品线 | MultiScreen® |
特点 | lid |
manufacturer/tradename | MultiScreen® |
technique(s) | DNA purification: suitable activity assay: suitable (with precipitations) ligand binding assay: suitable parallel artificial membrane permeation assay (PAMPA): suitable receptor binding assay: suitable |
板尺寸 | 96 wells |
孔最大体积 | 300 μL |
工作体积 | 125 μL |
孔径 | 0.4 μm pore size |
试验参数 | sample volume: 100 μL (per well) |
application(s) | sample preparation |
运输 | ambient |
Sigma-Aldrich