产品说明
一般描述
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Irregular expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
特异性
This antibody recognizes ASC.
免疫原
Full length recombinant human ASC.
Epitope: Unknown
应用
Research Sub Category
Apoptosis - Additional
Detect ASC using this Anti-ASC Antibody, clone 2EI-7 validated for use in WB, FC.
Research Category
Inflammation & Immunology
质量
Evaluated by Western Blot on mouse spleen tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected ASC in mouse spleen tissue lysate.
目标描述
~22 kDa
外形
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Format: Purified
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Mouse spleen tissue lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
质量水平 | 100 |
生物来源 | mouse |
抗体形式 | purified antibody |
antibody product type | primary antibodies |
克隆 | 2EI-7, monoclonal |
species reactivity | mouse |
species reactivity (predicted by homology) | human (based on 100% sequence homology) |
technique(s) | flow cytometry: suitable western blot: suitable |
同位素/亚型 | IgG1κ |
NCBI登记号 | NM_145182 |
UniProt登记号 | Q9ULZ3 |
运输 | wet ice |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich