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Anti-Beta Catenin Antibody, clone 7F7.2

品牌
Sigma-Aldrich
货号
04-958
规格纯度
clone 7F7.2, Upstate®, from mouse
参考价格
5016.79 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-Beta Catenin Antibody, clone 7F7.2
Beta Catenin, Catenin (cadherin-associated protein), beta 1
产品介绍:

产品说明

一般描述

Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.

特异性

This antibody recognizes beta catenin.

免疫原

Full length, GST-tagged recombinant beta catenin.

应用

This Anti-Beta Catenin Antibody, clone 7F7.2 is validated for use in WB, IC for the detection of Beta Catenin.
Research Category
Signaling
Western Blot Analysis: 0.5-2 µg/mL of this lot detected beta catenin in HEK293 cell lysate.
Research Sub Category
Developmental Signaling

质量

Routinely evaluated by western blot on HEK293 cell lysate.

目标描述

92 kDa

联系

Replaces: 04-1002

外形

Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HEK293 cell lysate, PC12 cell lysate, NIH/3T3 cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆7F7.2, monoclonal
species reactivityrat, human, mouse
manufacturer/tradenameUpstate®
technique(s)immunocytochemistry: suitable
western blot: suitable
同位素/亚型IgG1κ
NCBI登记号NP_001895
UniProt登记号P35222
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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