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位置:首页 > 品牌 > Sigma-Aldrich > Anti-BCL-11A Antibody, clone 3B12 ZooMAb® Rabbit Monoclonal

Anti-BCL-11A Antibody, clone 3B12 ZooMAb® Rabbit Monoclonal

品牌
Sigma-Aldrich
货号
ZRB1051
规格纯度
recombinant, expressed in HEK 293 cells
参考价格
2138.93 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-BCL-11A Antibody, clone 3B12 ZooMAb® Rabbit Monoclonal
EVI-9
B-cell CLL/lymphoma 11A
COUP-TF-interacting protein 1
Zinc finger protein 856
B-cell lymphoma/leukemia 11A
BCL-11A
Ecotropic viral integration site 9 protein homolog
产品介绍:

产品说明

一般描述

ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.

特异性

Clone 3B12 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects B-cell Lymphoma/leukemia 11 (BCL-11A). It targets an epitope within 20 amino acids from the N-terminal region.

免疫原

KLH-conjugated linear peptide corresponding to 20 amino acids from the N-terminal region of human B-cell Lymphoma/leukemia 11 (BCL-11A).

应用

Anti-BCL-11A, clone 3B12 ZooMAb, Cat. No. ZRB1051, is a recombinant Rabbit monoclonal antibody that specifically targets BCL-11A and is tested for use in and Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting.
Quality Control Testing
Immunohistochemistry (Paraffin) Analysis: A 1:1,000 dilution of this antibody detected BCL-11A in human tonsil tissue sections.Tested applicationsImmunocytochemistry Analysis: A 1:100 dilution from a representative lot detected BCL-11A in HeLa and A431 cells.Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected BCL-11A in Ramos and Raji cell lysates.Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user

目标描述

B-cell lymphoma/leukemia 11A (UniProt: Q9H165; also known as BCL-11A, B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, EVI-9, Zinc finger protein 856) is encoded by the BCL11A (also known as CTIP1, EVI9, KIAA1809, ZNF856) gene (Gene ID: 53335) in human. BCL-11A is a transcription factor associated with the BAF SWI/SNF chromatin remodeling complex that also acts as a repressor of fetal hemoglobin levels and plays a role in hematopoiesis. It is expressed at high levels in brain, spleen thymus, bone marrow and testis. Its expression has also been reported in CD34+ myeloid precursor cells, B-cells, monocytes and megakaryocytes. Its expression is tightly regulated during B-cell development. BCL-11A contains six C2H2 type zinc-finger regions. It is found in the nucleus as well as in the cytoplasm. In the absence of interaction between isoforms 1 and 2, it is predominantly localized in the cytoplasm and localizes to the nuclear paraspeckles when both isoforms are present. Chromosomal aberrations involving BCL11A gene are reported in B-cell malignancies. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals.

外形

Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.

重悬

300 μg/mL after reconstitution at 25 μL per vial. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

储存及稳定性

Recommend storage of lyophilized product at 2-8℃; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8℃, or -20℃ for long term storage. Avoid repeated freeze-thaws.

法律信息

ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源rabbit
质量水平200
重组expressed in HEK 293 cells
偶联物unconjugated
抗体形式purified antibody
克隆recombinant monoclonal
产品线ZooMAb® learn more
形式lyophilized
分子量calculated mol wt 91.20 kDa
species reactivityhuman, rat
species reactivity (predicted by homology)sheep, bovine
包装antibody small pack of 25 μL
环保替代产品特性Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
同位素/亚型IgG
环保替代产品分类Aligned
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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