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Anti-FKBP52 Antibody, clone 4H21 ZooMAb® Rabbit Monoclonal

品牌
Sigma-Aldrich
货号
ZRB1024
规格纯度
recombinant, expressed in HEK 293 cells
参考价格
2138.93 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-FKBP52 Antibody, clone 4H21 ZooMAb® Rabbit Monoclonal
FKBP51
51 kDa FK506-binding protein
FK506-binding protein 4
HSP-binding immunophilin
52 kDa FKBP
p59
FKBP59
Immunophilin FKBP52
FKBP-4
HBI
Peptidyl-prolyl cis-trans isomerase FKBP4
59 kDa immunophilin
FKBP-52
PPIase FKBP4
Rotamase
52 kDa FK506-binding protein
产品介绍:

产品说明

一般描述

ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.

特异性

Clone 4H21 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects FKBP52 protein. It targets an epitope within 21 amino acids from the C-terminal region.

免疫原

KLH-conjugated linear peptide corresponding to 21 amino acids from the C-terminal region of human FKBP52.

应用

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected FKBP52 in HEK293, NIH3T3, and L6 cell lysates.
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected FKBP52 in A431 and HepG2 cells.
Immunohistochemistry (Paraffin) Analysis: A 1:100 dilution from a representative lot detected FKBP52 in human testis tissue sections.
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Anti-FKBP52, clone 4H21 ZooMAb, Cat. No. ZRB1024, is a recombinant Rabbit monoclonal antibody that specifically targets FKBP52 and is tested for use in Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting.

目标描述

Peptidyl-prolyl cis-trans isomerase FKBP4 (UniProt: Q02790; also known as EC:5.2.1.8, PPIase FKBP4, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase) is encoded by the FKBP4 (also known as FKBP52) gene (Gene ID: 2288) in human. FKBP52 is a widely expressed, homodimeric protein that shuttles from the mitochondria to nucleus and co-localizes in mitochondria with the glucocorticoid receptor. It is an immunophilin protein that displays PPIase and co-chaperone activities. Its PPIase activity is attributed mainly to the first PPIase FKBP-type domain (aa 1-138) and the chaperone activity resides in the C-terminal region between amino acids 264 and 400. In the brain it is shown to colocalize with MAPT/TAU in the distal part of the primary cortical neurons. It acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. It I also a component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) and its phosphorylation by casein kinase 2 results in loss of HSP90 binding activity. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals.

外形

Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS, 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.

重悬

0.3 mg/mL after reconstitution at 25 μL per vial. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

储存及稳定性

Recommend storage of lyophilized product at 2-8℃; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8℃, or -20℃ for long term storage. Avoid repeated freeze-thaws.

法律信息

ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

质量水平200
生物来源rabbit (recombinant)
重组expressed in HEK 293 cells
偶联物unconjugated
抗体形式purified antibody
antibody product typeprimary antibodies
克隆4H21, monoclonal
recombinant monoclonal
产品线ZooMAb® learn more
形式lyophilized
分子量calculated mol wt 51.81 kDa
observed mol wt ~52 kDa
species reactivityhuman
包装antibody small pack of 25 μL
环保替代产品特性Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
增强验证recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
同位素/亚型IgG
环保替代产品分类Aligned
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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