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α-Synuclein Blocker, ELN484228-CAS 312-63-0-Calbiochem

品牌
Sigma-Aldrich
CAS
312-63-0
货号
5.30583
规格纯度
A cell-permeable compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells.
参考价格
1954.56 *本价格含增值税费
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数量
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产品名称:
312-63-0
α-Synuclein Blocker, ELN484228-CAS 312-63-0-Calbiochem
N-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228
产品介绍:

产品说明

一般描述

A cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type α-syn and microglia isolated from α-syn BAC transgenic animals over-expressing the E46K mutant form of human α-syn (~1-10 µM). Reduces α-syn-mediated impairment of vesicular dynamics and diminishes α-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µM) and in cortical cultures in transgenic mice over-expressing human α-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed α-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.
A cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type α-syn and microglia isolated from α-syn BAC transgenic animals over-expressing the E46K mutant form of human α-syn (~1-10 µM). Reduces α-syn-mediated impairment of vesicular dynamics and diminishes α-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µM) and in cortical cultures in transgenic mice over-expressing human α-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed α-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Cell permeable: yes
Primary Target
monomeric α-synuclein
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Toth, G., et al. 2014. PLoS ONE9, e87133.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C12H10FNO2S
分子量251.28
MDL编号MFCD00091019

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 100 mg/mL
储存温度2-8℃
InChI1S/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H
InChI keyAZORQGXJAXEIGC-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H319
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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