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位置:首页 > 品牌 > Sigma-Aldrich > SB-269970 Hydrochloride-CAS 261901-57-9-Calbiochem

SB-269970 Hydrochloride-CAS 261901-57-9-Calbiochem

品牌
Sigma-Aldrich
CAS
261901-57-9
货号
5.06415
包装型号
规格纯度
参考价格
2442.83 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
261901-57-9
SB-269970 Hydrochloride-CAS 261901-57-9-Calbiochem
5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
产品介绍:

产品说明

一般描述

A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).

生化/生理作用

Primary Target
5-HT₇

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Tokarski, K. et al. 2012. Pharmacol. Rep.64, 256.
Thomas. D. R. et al. 2000. Br. J. Pharmacol.130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem.43, 342.

Forbes, I. T. et al. 1998. J. Med. Chem.41, 655.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H28N2O3S · xHCl
分子量352.49 (free base basis)
MDL编号MFCD03788020

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: soluble
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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