InSolution IKK Inhibitor VII-CAS 873225-46-8-Calbiochem

产品名称：

873225-46-8
InSolution IKK Inhibitor VII-CAS 873225-46-8-Calbiochem
IKK 16, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII
(4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII, IKK 16

产品介绍：

产品说明

一般描述

A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC₅₀ = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
IKK-2, IKK complex, and IKK-1

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 µg/103 µL) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

其他说明

Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett.16, 108.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₈H₂₉N₅OS
分子量	483.63

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
储存温度	−70℃