您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > AMP Deaminase Inhibitor, Cpd3-Calbiochem

AMP Deaminase Inhibitor, Cpd3-Calbiochem

品牌
Sigma-Aldrich
货号
5.33642
包装型号
规格纯度
参考价格
2995.48 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
AMP Deaminase Inhibitor, Cpd3-Calbiochem
(S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMPD Inhibitor, AMP Deaminase Inhibitor
产品介绍:

产品说明

一般描述

A cell-permeable isoquinoline derivative that acts as a specific AMP competitive inhibitor of AMP deaminase (IC50 = 38, 27, and 24 nM for human, rat, and mice, respectively). Potentiates low frequency electrical stimulation induced increase in AMP level, AMP:ATP ratio, and phosphorylation of AMPK (at Thr172), and acetyl-CoA carboxylase (at Ser218) in contracting rat epitrochlearis muscle. However, it does not affect basal AMPK activity and contraction-stimulated glucose uptake. Preincubation with this compound reduces basal IMP levels, but does affect the contraction-induced increases in IMP, adenosine, and inosine in any appreciable manner.

生化/生理作用

Cell permeable: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Admyre, T., et al. 2014. Chem. Biol.21, 1486.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C24H21N3O2
分子量383.44

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
效能38 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 50 mg/mL
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品