JNK Inhibitor VIII-CAS 894804-07-0-Calbiochem

产品说明

一般描述

A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (K_i = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC₅₀ of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target K_i: 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively
Product competes with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

其他说明

Vivanco, I., et al. 2007. Cancer Cell11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem.49, 3563.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

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