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MMP-2 Inhibitor III-CAS 704888-90-4-Calbiochem

品牌
Sigma-Aldrich
CAS
704888-90-4
货号
444288
规格纯度
The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
参考价格
4224.61 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
704888-90-4
MMP-2 Inhibitor III-CAS 704888-90-4-Calbiochem
(2-((Isopropoxy)-(1,1'-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
产品介绍:

产品说明

一般描述

A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 >50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
MMP-2
Product does not compete with ATP.
Reversible: no
Target IC50: 12 nM against MMP-2

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Tuccinardi, T., et al. 2006. Bioorg. Med. Chem.14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C17H20N2O5S
分子量364.42

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性methanol: 100 mg/mL
DMSO: 200 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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