1400W-CAS 214358-33-5-Calbiochem

品牌

Sigma-Aldrich

CAS

214358-33-5

货号

100050

包装型号

5 MG, A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; K_d = 7 nM).

规格纯度

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; K_d = 7 nM).

参考价格

2340.22 元 *本价格含增值税费

促销

数量

产品名称：

214358-33-5
1400W-CAS 214358-33-5-Calbiochem
N-(3-Aminomethyl)benzylacetamidine, 2HCl

产品介绍：

产品说明

一般描述

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; K_d = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
A selective, irreversible, slow, tight binding inhibitor of inducible nitric oxide synthase (iNOS, K_d = 7 nM) both in vitro and in vivo. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
iNOS
Product does not compete with ATP.
Reversible: no
Kd = 7 nM against inducible nitric oxide synthase (iNOS)

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.

其他说明

Parmentier, S., et al. 1999. Br. J. Pharmacol.127, 546.
Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₀H₁₅N₃ · 2HCl
分子量	250.17
MDL编号	MFCD03428622

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	water: 1 mg/mL methanol: 5 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C10H16N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5,13H,6-7,11-12H2,1H3/q+1/p+1
InChI key	FFSSUWWXUDLVQZ-UHFFFAOYSA-O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable