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βARK1 Inhibitor-CAS 24269-96-3-Calbiochem

品牌
Sigma-Aldrich
CAS
24269-96-3
货号
182200
规格纯度
The βARK1 Inhibitor, also referenced under CAS 24269-96-3, controls the biological activity of βARK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2340.22 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
24269-96-3
βARK1 Inhibitor-CAS 24269-96-3-Calbiochem
β-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
产品介绍:

产品说明

一般描述

A selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1) (IC50 = 126 µM). Has no inhibitory activity against protein kinase A (PKA).
A selective inhibitor of β-adrenergic receptor kinase 1 (βARK1) (IC50 = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit βARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between βARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of βARK1 desensitize agonist-bound β2-adrenergic receptors.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
βARK1 (β-Adrenergic Receptor Kinase 1)
Product does not compete with ATP.
Reversible: no
Target IC50: 126 µM against βARK1 (β-Adrenergic Receptor Kinase 1)
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Iino, M., et al. 2002. J. Med. Chem.45, 2150.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C12H9NO6
分子量263.20

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow to orange
溶解性DMSO: 5 mg/mL
methanol: soluble
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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