CGP-37157-CAS 75450-34-9-Calbiochem

产品说明

一般描述

A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na⁺/Ca²⁺ exchanger (IC₅₀ = 360 nM). Enhances the export of Ca²⁺ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca²⁺ channels.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 360 nM against mitochondrial Na+/Ca2+ exchanger
Product does not compete with ATP.
Reversible: no
Primary Target
Mitochondrial Na+/Ca2+ exchanger

警告

Toxicity: Standard Handling (A)

制备说明

Dilute in Ca²⁺-free buffer just prior to use.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Jornot, L., et al. 1999. J. Cell Sci.112, 1013.
Babcock, D.F., et al. 1997. J. Cell Biol.136, 833.
Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol.340, 295.
Griffiths, E.J., et al. 1997. Cell Calcium21, 321.
White, R.J., and Reynolds, I.J. 1996, J. Neurosci.16, 5688.
Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol.21, 595.
Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem.268, 938.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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