Heat Shock Protein Inhibitor I-CAS 218924-25-5-Calbiochem

产品说明

一般描述

A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
Hsp70
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.

其他说明

Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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