IC261-CAS 186611-52-9-Calbiochem

产品说明

一般描述

A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC₅₀ = 0.7-1.3 µM) and CK1ε (IC₅₀ = 0.6-1.4 µM) isozymes. Also inhibits CK1α₁ at much higher concentrations (IC₅₀ = 11-21 µM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34^cdc2 and p55^fyn (IC₅₀s >100 µM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC₅₀ = 0.7-1.3 µM) and CK1ε (IC₅₀ = 0.6-1.4 µM) isozymes. Also inhibits CK1α₁ at much higher concentrations (IC₅₀ = 11-21 µM). The inhibition is competitive with respect to ATP. Only weakly inhibits PKA, p34^cdc2, and p55^fyn (IC₅₀s >100 µM). At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
CK1δ
Product competes with ATP.
Reversible: yes
Target IC₅₀: 0.7-1.3 µM, 0.6-1.4 µM, against CK1δ and CK1ε isozymes, respectively

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C when stored under an inert gas.

其他说明

Behrend, L., et al. 2000. Oncogene19, 5303.
Mashhoon, N., et al. 2000. J. Biol. Chem.275, 20052.
Knippschild, U., et al. 1997. Oncogene15, 1727.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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