JAK3 Inhibitor II-CAS 211555-04-3-Calbiochem

产品说明

一般描述

A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC₅₀ = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.
A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3. Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-jun in DT-40 cells.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
JAK-3
Product competes with ATP.
Target IC₅₀: 5.6 µM against JAK3
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ghosh, S., et al. 2001. Acta Crystallogr. C.57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res.4, 2463.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息