您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Myosin Light Chain Kinase Inhibitor Peptide 18-Calbiochem

Myosin Light Chain Kinase Inhibitor Peptide 18-Calbiochem

品牌
Sigma-Aldrich
货号
475981
规格纯度
The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
3543.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Myosin Light Chain Kinase Inhibitor Peptide 18-Calbiochem
MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH2, MLCK Inhibitor IV
H-RKKYKYRRK-NH2, MLCK Inhibitor Peptide 18, MLCK Inhibitor IV
产品介绍:

产品说明

一般描述

A highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
A highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC50: 50 nM against MLCK
Product does not compete with ATP.
Primary Target
Mlck
Cell permeable: yes
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Zolotarevsky, Y., et al. 2002. Gastroenterology123, 163.
Lukas, T.J., et al. 1999. J. Med. Chem.42, 910.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C60H105N23O11
分子量1324.62

产品性质

质量水平100
测定≥97% (HPLC)
形式lyophilized solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性water: 1 mg/mL
DMSO: 5 mg/mL
运输wet ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品