您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > PIM1/2 Kinase Inhibitor VI-CAS 587852-28-6-Calbiochem

PIM1/2 Kinase Inhibitor VI-CAS 587852-28-6-Calbiochem

品牌
Sigma-Aldrich
CAS
587852-28-6
货号
526524
规格纯度
The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
1763.65 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
587852-28-6
PIM1/2 Kinase Inhibitor VI-CAS 587852-28-6-Calbiochem
(Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a
SMI-16a, (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione
产品介绍:

产品说明

一般描述

A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Xia, Z., et al. 2009. J. Med. Chem.52, 74.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C13H13NO3S
分子量263.31

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 25 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品