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位置:首页 > 品牌 > Sigma-Aldrich > Polo-like Kinase Inhibitor V, Poloxin-CAS 321688-88-4-Calbiochem

Polo-like Kinase Inhibitor V, Poloxin-CAS 321688-88-4-Calbiochem

品牌
Sigma-Aldrich
CAS
321688-88-4
货号
528884
规格纯度
The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2340.22 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
321688-88-4
Polo-like Kinase Inhibitor V, Poloxin-CAS 321688-88-4-Calbiochem
Polo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone
产品介绍:

产品说明

一般描述

A thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Reindl, W., et al. 2008. Chem Biol.15, 459.
Yuan, J., et al. 2011, Am J Pathol179, 2091.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H19NO3
分子量297.35
MDL编号MFCD00534351

产品性质

质量水平100
测定≥99% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 25 mg/mL, clear, yellow
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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