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TOFA-CAS 54857-86-2-Calbiochem

品牌
Sigma-Aldrich
CAS
54857-86-2
货号
613450
规格纯度
A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis.
参考价格
4923.29 *本价格含增值税费
促销
服务
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  • 包邮
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数量
-+
产品名称:
54857-86-2
TOFA-CAS 54857-86-2-Calbiochem
5-(Tetradecyloxy)-2-furoic acid
产品介绍:

产品说明

一般描述

A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
A cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Acetyl-CoA carboxylase (ACC)
Target IC50: 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7
Reversible: yes
Cell permeable: yes
Product competes with ATP.

警告

Toxicity: Carcinogenic / Teratogenic (D)

制备说明

Slight warming and sonication may be required for complete solubilization in ethanol.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Landree, L.E., et al. 2004. J. Biol. Chem.279, 3817.
Zhou, W., et al. 2003. Cancer Res.63, 7330.
Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA100, 12624.
Pizer, E.S., et al. 2000. Cancer Res.60, 213.
Arbeeny, C.M., et al. 1992. J. Lipid Res.33, 843.
Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res.25, 831.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C19H32O4
分子量324.45
MDL编号MFCD01726059

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 10 mg/mL
ethanol: 5 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
InChI keyCZRCFAOMWRAFIC-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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