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VEGFR2 Kinase Inhibitor VI, Ki8751-CAS 228559-41-9-Calbiochem

品牌
Sigma-Aldrich
CAS
228559-41-9
货号
676484
规格纯度
The VEGFR2 Kinase Inhibitor VI, Ki8751, also referenced under CAS 228559-41-9, controls the biological activity of VEGFR2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
3945.15 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
228559-41-9
VEGFR2 Kinase Inhibitor VI, Ki8751-CAS 228559-41-9-Calbiochem
N-(2,4-Difluorophenyl)-N'-(4-(6,7-dimethoxy-4-quinolyloxy)-2-fluorophenyl)urea, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor VI, VEGFR Tyrosine Kinase Inhibitor XXIV
产品介绍:

产品说明

一般描述

A cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitior in both cell-based (IC50 = 0.9 nM in VEGF-induced receptor phosphorylation) and cell-free (IC50 = 4.0 nM in kinase reactions) assays. It inhibits c-Kit, PDGFRα, and FGFR-2 only at much higher concentrations (IC50 = 40, 67, and 170 nM, respectively, in cell-based assays), while exhibiting no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 µM. Effectively blocks VEGF-dependent, but not VEGF-independent, cell proliferation in vitro and tumor growth in mice and rats (5 to 20 mg/kg, daily p.o.) in vivo.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Kubo, K., et al. 2005. J. Med. Chem.48, 1359.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C24H18F3N3O4
分子量469.41

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性DMSO: 50 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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