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AG 126-CAS 118409-62-4-Calbiochem

品牌
Sigma-Aldrich
CAS
118409-62-4
货号
658452
规格纯度
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.
参考价格
2340.22 *本价格含增值税费
促销
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数量
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产品名称:
118409-62-4
AG 126-CAS 118409-62-4-Calbiochem
α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
产品介绍:

产品说明

一般描述

A cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).

包装

5 mg in Alu drum

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
COX-2 activity
Target IC50: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells

警告

Toxicity: Toxic (F)

其他说明

Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C10H5N3O3
分子量215.17

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 5 mg/mL
DMF: soluble
运输ambient
储存温度−20℃
InChI1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
InChI keyDUQADSPERJRQBW-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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