产品说明
一般描述
Interleukin-11 (IL-11) is synthesized by many mesenchymal origin cells like keratinocytes, synoviocytes, fibroblasts, bone marrow stromal cells, osteoblasts, and chondrocytes.
The gene IL-11 (interleukin 11) is mapped to human chromosome 19q13.4. It is a secreted protein.
生化/生理作用
Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling.
Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.
外形
Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein.
分析说明
The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11.
基本信息
| MDL编号 | MFCD00212208 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in baculovirus infected Sf21 cells |
| 测定 | >97% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 0.06-0.24 ng/mL ED50 |
| 分子量 | 23 kDa |
| 包装 | pkg of 5 μg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P20809 |
| 储存温度 | −20℃ |
| Gene Information | human ... IL11(3589) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
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