Anti-Endoglin Antibody, clone P3D1

产品说明

一般描述

Endoglin is a homodimeric integral membrane glycoprotein comprised of 95 kDa subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family ligands to signaling receptors. Endoglin binds TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. It is also expressed by U937 cells and activated macrophages. Endoglin expression is up regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

特异性

Reacts with human endoglin.

免疫原

Human resting umbilical vein endothelial cells.

应用

Research Sub Category
Growth Factors & Receptors
Anti-Endoglin Antibody, clone P3D1 is an antibody against Endoglin for use in WB, IH, IC, IP, FC, ELISA.
Research Category
Signaling
Immunohistochemistry: For use on acetone or paraformaldehyde fixed tissue.
ELISA: A previous lot of this antibody was used in ELISA.
Immunoprecipitation: A previous lot of this antibody was used in IP.
Immunocytochemistry: A previous lot of this antibody was used in IC.
Flow Cytometry: A previous lot of this antibody was used in FC.
Optimal working dilutions must be determined by the end user.

质量

Routinely evaluated by Western Blot on Jurkat lysates.
Western Blot Analysis: 1:500 dilution of this lot detected ENDOGLIN on 10 μg of Jurkat lysates.

目标描述

~71 kDa

联系

Replaces: MAB2152

外形

Purified
Format: Purified
Purified mouse monoclonal IgG2a in 0.02M phosphate buffer, 0.25M sodium chloride, 0.1% sodium azide, pH 7.6

储存及稳定性

Stable at 2-8°C for up to 1 year from date of receipt.

分析说明

Control
Jurkat cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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