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位置:首页 > 品牌 > Sigma-Aldrich > Anti-U1-70K Antibody, clone 9C4.1

Anti-U1-70K Antibody, clone 9C4.1

品牌
Sigma-Aldrich
货号
05-1588
规格纯度
clone 9C4.1, from mouse
参考价格
5520.38 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-U1-70K Antibody, clone 9C4.1
small nuclear ribonucleoprotein 70kDa (U1), U1 small nuclear ribonucleoprotein 70 kDa, small nuclear ribonucleoprotein 70kDa (RNP antigen), U1 snRNP 70 kDa
产品介绍:

产品说明

一般描述

U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) is one of three specific proteins found within the U1 snRNP core, which includes at least seven core proteins found in all U snRNPs and three specific proteins; U1-70K, U1-A, and U1-C. U1-70K is involved in mediating pre-mRNA splicing through binding the loop I region of U1-snRNA with its RPM (RNA recognition motif) binding domain. In addition, its RNA binding domain, U1-70K also contains two argine-rich regions, accented with acidic or serine residues, that is thought to have trans-acting functions. Alternative splicing results in 4 known isoforms. Truncated forms of U1-70K are unable to bind RNA.

特异性

This antibody recognizes U1-70K at the C-terminal domain.

免疫原

Epitope: C-terminal domain
Recombinant protein corresponding to C-terminal domain of human U1-70K.

应用

Use Anti-U1-70K Antibody, clone 9C4.1 (Mouse Monoclonal Antibody) validated in WB, ICC to detect U1-70K also known as small nuclear ribonucleoprotein 70kDa (U1).
Immunocytochemistry Analysis: A 1:500 dilution of a representative lot of this antibody has been shown to detect U1-70K in NIH/3T3, A431, and HeLa cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins

质量

Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected U1-70K on 10 µg of HeLa cell lysate.

目标描述

Calculated 52 kDa Observed ~57 kDa

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HeLa cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified antibody
antibody product typeprimary antibodies
克隆9C4.1, monoclonal
species reactivitymouse, human, rat
technique(s)immunocytochemistry: suitable
western blot: suitable
同位素/亚型IgG2aκ
NCBI登记号NP_003080.2
UniProt登记号P08621
运输wet ice
Gene Informationhuman ... SNRNP70(6625)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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