产品说明
一般描述
C8 Ceramide is a short chain ceramide and is cell permeable.
应用
C8 Ceramide (d18:1/8:0) has been used as an internal ceramide standard in electrospray ionization. It has also been used as a substrate for ceramide kinase activity assay. It is suitable for use as a substrate for galactocerebrosidase.
生化/生理作用
C8 Ceramide has anti-tumor functionality. Synthetic liposomal C8 ceramide inhibits hepatocellular carcinoma (HCC). Addition of exogenous C8 ceramide causes necrosis in hepatocytes by decreasing ATP levels and impairing mitochondrial functionality. C8 ceramide inhibition of serine palmitoyl transferase halts de novo sphingolipid biosynthesis. It also acts as chemotherapeutic agent by increasing the reactive oxygen species in lung cancer cells.
包装
5 mL Amber Glass Screw Cap Vial (860508P-5mg)
基本信息
| 经验(实验)分子式 | C26H51NO3 |
| 分子量 | 425.69 |
| NACRES | NA.25 |
产品性质
| 形式 | powder |
| 包装 | pkg of 1 × 5 mg (860508P-5mg) |
| manufacturer/tradename | Avanti Polar Lipids 860508P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
Sigma-Aldrich
m.cnreagent.com
