(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione

产品名称：

74772-77-3
Ciglitizone
(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione
Ciglitazone

产品介绍：

产品说明

应用

Ciglitizone has been used as a proliferator-activated receptor γ (PPARγ) agonist:

to study its effects on cell proliferation in human melanocytes
to study its effects on pigmentation and migration of human melanocytes

It also may be used to study its effects on cell cycle and apoptosis in monocytic cells.

包装

5 mg in glass insert

生化/生理作用

Ciglitizone belongs to the class of thiazolidinediones and is a peroxisome proliferator-activated receptor γ (PPARγ) agonist. It exhibits anti-diabetic activity. Ciglitizone has the potential to treat tumor necrosis factor α (TNFα)-related apoptosis-inducing ligand (TRAIL)-refractory high-grade urothelial cancers.

特点和优势

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₈H₂₃NO₃S
分子量	333.45
MDL编号	MFCD00865499
PubChem化学物质编号	24892661
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
创始人	Takeda
SMILES string	CC1(CCCCC1)COc2ccc(CC3SC(=O)NC3=O)cc2
InChI	1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
InChI key	YZFWTZACSRHJQD-UHFFFAOYSA-N
Gene Information	human ... PPARG(5468) mouse ... Pparg(19016)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)