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Topo I (197-651) (core domain) human

品牌
Sigma-Aldrich
货号
SRP2033
规格纯度
recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
参考价格
7018.5 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Topo I (197-651) (core domain) human
TOPI
产品介绍:

产品说明

生化/生理作用

Human DNA topoisomerase I is the best studied of the DNA topoisomerase family. It catalyzes the relaxation of both positive and negative supercoils without the requirement of energy. In addition to DNA replication and transcriptional activation, DNA topoisomerase I also plays a major role in pre-mRNA splicing, cell cycle and other gene regulatory pathways during cell growth and development. The core domain spanning from amino acids 215 to 636 is highly conserved and retains DNA binding activity. Topo I has been found to nick the DNA with a preference of 5′-(A/T)(G/C)(A/T)T-3′. Camptothecin and its analogs have been tested as potent anticancer compounds by stabilizing topo I-DNA complex, thereby inhibiting both DNA and RNA synthesis.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

产品性质

生物来源human
重组expressed in insect cells
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~56 kDa
包装pkg of 5 μg
储存条件avoid repeated freeze/thaw cycles
浓度500 μg/mL
颜色clear colorless
NCBI登记号NM_003286
UniProt登记号P11387
运输dry ice
储存温度−70℃
Gene Informationhuman ... TOP1(7150)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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