2-AG

产品名称：

53847-30-6
2-AG

产品介绍：

产品说明

一般描述

2-Arachidonoylglycerol (2-AG), is an endocannabinoid, an endogenous agonist of the CB1 receptor. 2-AG, unlike anandamide, is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in mouse and rat brain (~5-10 nmol/g tissue). Detection of 2-AG in brain tissue is complicated by the relative ease of its isomerization to 1-AG during standard lipid extraction conditions. Unlike anandamide, formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol lipase (DAGL). 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is hydrolyzed in vitro by monoacylglycerol lipase (MAGL), fatty acid amide hydrolase (FAAH), and the uncharacterized serine hydrolase enzymes ABHD6 and ABHD12.

包装

5 mL PTFE Vial with Screw Cap/Argon/Foil Bag (870450O-5mg)

基本信息

经验(实验)分子式	C₂₃H₃₈O₄
分子量	378.55
NACRES	NA.25

产品性质

包装	pkg of 1 × 5 mg (with screw cap/argon/foil bag (870450O-5mg))
manufacturer/tradename	Avanti Polar Lipids 870450O
运输	dry ice
储存温度	−20℃
SMILES string	[H]C(CO)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)CO
InChI	1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
InChI key	RCRCTBLIHCHWDZ-DOFZRALJSA-N

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3