产品说明
一般描述
6-keto-5α-hydroxycholesterol, also known as 6-oxo-cholestan-3β,5α-diol (OCDO), is synthesized from the oxidation of 5β, 6β-epoxycholesterol in the presence of enzyme cholesterol epoxide hydrolase. It is also synthesized from cholestane-3β,5α,6β-triol by the enzyme 11β-hydroxysteroid dehydrogenase type II . The enzyme 11β-hydroxysteroid dehydrogenase type I catalyzes the reduction of OCDO to cholestane-3β,5α,6β-triol.
生化/生理作用
6-keto-5α-hydroxycholesterol favors tumor progression. cholestan-6-oxo-3β,5α-diolelicits cytotoxicity towards human bronchial 16-HBE cells and plays a key role in mediating cell necrosis post ozone exposure. It is an oncometabolite, which promotes breast cancer progression and also blocks chemotaxis mediated by polymorphonuclear leukocytes.
包装
5 mL Amber Glass Screw Cap Vial (700140P-5mg)
基本信息
| 经验(实验)分子式 | C27H46O3 |
| 分子量 | 418.65 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 5 mg (700140P-5mg) |
| manufacturer/tradename | Avanti Polar Lipids 700140P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| InChI | 1S/C27H46O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-23,28,30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,25-,26-,27+/m1/s1 |
| InChI key | SJZZRXMQSAXCFD-ZCBMJONGSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
Sigma-Aldrich
m.cnreagent.com
