产品说明
一般描述
The SMARCA4 (SWI/SNF (SWItch/sucrose non-fermentable) related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) gene is mapped to human chromosome 19p13.2. The protein encoded by the SMARCA4 gene is an ATPases transcription activator with multisubunits (12-15).
生化/生理作用
BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and is implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Mutation of lysine to arginine at position 798 in the DNA-dependent ATPase domain of BRG1 a) failed to restore normal growth to swi2- cells, b) reduced its ability to repress c-fos transcription, and c) reduced CIITA (class II transactivator) induction and enhanced the rate of induction of the interferon-g-responsive GBP-1 gene.
外形
Clear and colorless frozen liquid solution
制备说明
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
基本信息
| NACRES | NA.26 |
产品性质
| 生物来源 | human |
| 重组 | expressed in insect cells |
| 测定 | ≥80% (SDS-PAGE) |
| 形式 | frozen liquid |
| 分子量 | ~185 kDa |
| 包装 | pkg of 5 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 浓度 | 300 μg/mL |
| 颜色 | clear colorless |
| NCBI登记号 | NM_003072 |
| UniProt登记号 | P51532 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... SMARCA4(6597) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
