产品名称：
119567-63-4
Dimethyl Sphingosine (d18:1)
(2R,3S,E)-2-(dimethylamino)octadec-4-ene-1,3-diol
N,N-DMS
D-erythro-N,N-dimethylsphingosine
产品介绍：
产品说明
一般描述
Dimethyl Sphingosine (d18:1), also called as N,N-Dimethyl-d-erythro-sphingosine (DMS), is a natural sphingolipid metabolite. It is found in various tissues.
应用
Dimethyl Sphingosine (d18:1) may be used:
- to investigate D-erythro-N,N-dimethylsphingosine (DMS)-induced cell death in U937 cells to understand its molecular mechanism
- to study its effects on intracellular Ca2+ concentration, pH and glutamate uptake in human 1321N1 astrocytes
- in substrate specificity studies of sphingosine methyltransferase activity in rat kidney homogenate
Dimethyl sphingosine (d18:1) has been used as an inhibitor of sphingosine kinase.
生化/生理作用
D-erythro-N,N-dimethylsphingosine (DMS) prevents the activity of sphingosine kinase and protein kinase C. It modulates cellular activities. DMS exhibits anti-cancer and apoptotic properties. It is involved in the augmentation of epidermal growth factor receptor (EGFR) and inhibition of src kinase. DMS functions as a potential therapeutic for Chagas disease cardiomyopathy through its anti-parasitic and immunomodulatory properties.
D-erythro-N,N-dimethylsphingosine (DMS) has an ability to inhibit the activity of sphingosine kinase. It also helps to study the role of sphingosine 1-phosphate (SPP) as an intracellular second messenger. DMS exhibits anti-parasitic and immunomodulatory activities. It acts as a potential therapeutic for chronic Chagas disease cardiomyopathy.
包装
5 mL Clear Glass Sealed Ampule (860496O-5mg)
基本信息
| 经验(实验)分子式 | C20H41NO2 |
| 分子量 | 327.55 |
| NACRES | NA.25 |
产品性质
| 包装 | pkg of 1 × 5 mg (860496O-5mg) |
| manufacturer/tradename | Avanti Polar Lipids 860496O |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | OC[C@@](N(C)C)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC |
| InChI | 1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1 |
| InChI key | YRXOQXUDKDCXME-YIVRLKKSSA-N |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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