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Flt-3/Flk-2 Ligand from mouse

品牌
Sigma-Aldrich
货号
F9175
规格纯度
≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
参考价格
4015.66 *本价格含增值税费
促销
服务
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数量
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产品名称:
Flt-3/Flk-2 Ligand from mouse
产品介绍:

产品说明

一般描述

Flt3l (FMS-like tyrosine kinase 3 ligand) is a cytokine and a hematopoietic growth factor. It acts as a ligand for FLT3 receptor. Alternative splicing of FLT3L results in both membrane-bound and soluble forms. Soluble form is a result of proteolytic cleavage of the membrane isoform. It has a wide range of tissue expression.
Mouse and human Flt-3 ligand share approximately 72% homology and both demonstrate cross-species activity.

生化/生理作用

Flt3l (FMS-like tyrosine kinase 3 ligand) acts as a stimulant of hematopoietic progenitor cell proliferation. It facilitates the commitment of lymphoid lineage, and aids in dendritic cell (DC) development. It is involved in myeloblast differentiation, and drives skeletal muscle regeneration. It acts on p120RasGAP and suppresses Erk signaling, which in turn promotes myogenesis. In lymphoid tissues, it modulates DC homeostasis, which is facilitated by steady state as well as proliferative T-cells.

质量

Heterogenous glycosylation causes recombinant mouse Flt-3 ligand to migrate as multiple bands from 18-32 kDa.

外形

Lyophilized from a 0.2 μm filtered solution in 50% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

分析说明

Bioactivity is measured by the ability to stimulate the proliferation of a Flt-3 transfected pro-B cell line.

基本信息

MDL编号MFCD01093789
NACRESNA.32

产品性质

质量水平100
生物来源mouse
重组expressed in NSO cells
测定≥97% (SDS-PAGE)
形式lyophilized powder
效能1.0-4.0 ng/mL
分子量 ~18 kDa
包装pkg of 5 μg
储存条件avoid repeated freeze/thaw cycles
technique(s)cell culture | mammalian: suitable
杂质 endotoxin, tested
UniProt登记号P49772
储存温度−20℃
Gene Informationmouse ... Flt3l(14256)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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