产品名称:
30354-18-8
N,N-Dimethylmethyleneiminium chloride
Böhme′s salt
Dimethylformiminium chloride
Böhme′s salt
Methylenedimethylammonium chloride
N , N -二甲基亚甲蓝
Eschenmoser 盐
产品介绍:
产品说明
应用
N,N-Dimethylmethyleneiminium chloride (Böhme′s salt) is a dimethylaminomethylating agent that can be used as one of the key reagents in the following applications:
- Electrophilic aminomethylation of aldehydes and ketones to synthesize corresponding Mannich products, also known as Mannich reaction.
- Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors.
- Preparation of cyanotetrahydrooxo-β-carbolines via cyclocondensation of cyanomethyl indole-2-carboxylate with ammonia.
- Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan.
- Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX).
- Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps.
Reacant for:
Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors
Mannich reactions
Preparation of cyanotetrahydrooxo-ß-carbolines via cyclocondensation reactions
Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan
Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX)
Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps
包装
5, 25 g in glass bottle
其他说明
供直接使用的"Mannich 试剂";与传统的"Mannich 反应"相比,可在更短时间内生成产量和纯度更高的产物;与三氟甲磺酸三甲基硅酯原位制备反应性三氟甲磺酸盐
基本信息
线性分子式 | CH2=N+(CH3)2Cl- |
分子量 | 93.56 |
Beilstein | 505955 |
EC 号 | 250-142-4 |
MDL编号 | MFCD00011809 |
PubChem化学物质编号 | 57650016 |
NACRES | NA.22 |
产品性质
质量水平 | 100 |
测定 | ≥95.0% (AT) |
reaction suitability | reaction type: C-C Bond Formation |
mp | 146-148 ℃ (lit.) |
SMILES string | [Cl-].C[N+](C)=C |
InChI | 1S/C3H8N.ClH/c1-4(2)3;/h1H2,2-3H3;1H/q+1;/p-1 |
InChI key | ZJTROANVDZIEGB-UHFFFAOYSA-M |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H228 - H315 - H319 - H335 |
预防措施声明 | P210 - P302 + P352 - P305 + P351 + P338 |
危险分类 | Eye Irrit. 2 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3 |
靶器官 | Respiratory system |
储存分类代码 | 4.1B - Flammable solid hazardous materials |
WGK | WGK 3 |
闪点(F) | 179.6 °F - closed cup |
闪点(C) | 82 ℃ - closed cup |
个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |