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2-((3-Trifluoromethyl)phenyl)histamine dimaleate

2-((3-三氟甲基)苯基)组胺二马来酸酯

品牌
Sigma-Aldrich
CAS
162049-83-4
货号
T4951
规格纯度
≥98% (HPLC), powder
参考价格
2248.07 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
162049-83-4
2-((3-Trifluoromethyl)phenyl)histamine dimaleate
Compound 39
(2-[2-(3-Trifluoromethyl)phenyl)-1H-imidazol-4-yl]ethanamine dimaleate
2-((3-三氟甲基)苯基)组胺二马来酸酯
产品介绍:

产品说明

应用

2-((3-Trifluoromethyl)phenyl)histamine dimaleate has been used to study the induction of goblet cell secretion in rats3. 2-((3-Trifluoromethyl)phenyl)histamine dimaleate has also been used to study the role of H1 receptor in COX-2 regulation and prostanoid homeostasis in human vascular endothelial cells4.

包装

5 mg in glass bottle

生化/生理作用

2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be the most potent and selective H1 histamine receptor agonist of a panel of compounds in functional in vitro studies on histamine H2, H3, and other neurotransmitter receptors. It showed better potency at the guinea pig H1 histamine receptor than at the human H1 histamine receptor (pKi : 5.9). The selectivity of 2-((3-Trifluoromethyl)phenyl)histamine dimaleate was found to be 2138 (H1:H2), > 64 (H1:H3), 1000 (H1:M3), 105 (H1: a1), 708 (H11), and 71 (H1:5HT2A). 2-((3-Trifluoromethyl)phenyl)histamine dimaleate does not cross the blood-brain barrier.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

2-((3-Trifluoromethyl)phenyl)histamine dimaleate is soluble in water at approximately 20 mg/ml.

基本信息

经验(实验)分子式C20H20F3N3O8
分子量487.38
MDL编号MFCD08277024
PubChem化学物质编号329826803
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 off-white
溶解性H2O: ~20 mg/mL
储存温度2-8℃
SMILES stringOC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.NCCc1c[nH]c(n1)-c2cccc(c2)C(F)(F)F
InChI1S/C12H12F3N3.2C4H4O4/c13-12(14,15)9-3-1-2-8(6-9)11-17-7-10(18-11)4-5-16;2*5-3(6)1-2-4(7)8/h1-3,6-7H,4-5,16H2,(H,17,18);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChI keyGGDUVPKRZGATLR-SPIKMXEPSA-N

安全信息

象形图GHS05GHS06
警示用语:Danger
危险声明H301 - H315 - H318 - H335
预防措施声明P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
危险分类Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Sigma-Aldrich

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