Bepristat 1a

产品名称：

1642375-66-3
Bepristat 1a
1-[(3-Chloro-4-hydroxyphenyl)methyl]-N-ethyl-N-methyl-4-(2-phenoxyethyl)-4-piperidinecarboxamide

产品介绍：

产品说明

生化/生理作用

Bepristat 1a is a selective reversible inhibitor of protein disulfide isomerase (PDI), an enzyme in the endoplasmic reticulum that catalyzes disulfide bond breakage and reformation to catalyze protein folding. Unlike most PDI inhibitors, Bepristat 1a binds at the substrate-binding site, rather than the catalytic site. It blocked PDI activity with an IC50 value of 700 nM. PDI is up-regulated in several cancers, has been implicated in neurodegenerative processes, and plays an important role in thrombus formation. Bepristat 1a potently inhibited platelet aggregation and thrombus formation in vivo.

基本信息

经验(实验)分子式	C₂₄H₃₁ClN₂O₃
分子量	430.97
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to light brown
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	ClC1=C(O)C=CC(CN2CCC(C(N(CC)C)=O)(CCOC3=CC=CC=C3)CC2)=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable