N,N′-(Naphthalene-1,4-diyl)bis(4-methoxybenzenesulfonamide)

产品名称：

321694-20-6
Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene
Compound 16
N,N′-(Naphthalene-1,4-diyl)bis(4-methoxybenzenesulfonamide)

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene is a non-covalent inhibitor of the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2). The Keap1–Nrf2 protein–protein interaction is considered a critical point of the Keap1–Nrf2–ARE (antioxidant response elements) system that protects cells from oxidative stress. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene prevents Keap1 repression of Nrf2 activation, allowing Nrf2 to initiate antioxidant response element (ARE) to protect the cell. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene has an IC₅₀of 2.7 micromolar and specifically binds to the Keap1 Kelch-DC domain.

特点和优势

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基本信息

经验(实验)分子式	C₂₄H₂₂N₂O₆S₂
分子量	498.57
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	, white to light yellow to light gray
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable