CINK4

产品名称：

359886-84-3
CINK4
trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC₅₀ = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.

基本信息

经验(实验)分子式	C₂₇H₃₂N₆O
分子量	456.58
PubChem化学物质编号	329825807

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	powder
颜色	white to light brown
溶解性	DMSO: 25 mg/mL, clear
储存温度	2-8℃
SMILES string	O[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1
InChI	1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23-
InChI key	YVXCDLCJCIDFHE-AFARHQOCSA-N

安全信息

储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable