CK-869

产品名称：

388592-44-7
CK-869
CK-0157869
CK 869
2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone

产品介绍：

产品说明

应用

CK-869 has been used as an Arp2/3 complex inhibitor:

to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
to induce membrane blebbing in HT1080 fibrosarcoma cells
to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

包装

5, 25 mg in glass bottle

生化/生理作用

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

基本信息

经验(实验)分子式	C₁₇H₁₆BrNO₃S
分子量	394.28
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to light gray
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable